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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
10.61
Human Site:
T553
Identified Species:
16.67
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
T553
E
E
D
S
S
G
H
T
R
A
Y
G
V
C
F
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
T553
E
E
D
S
S
G
H
T
R
A
Y
G
V
C
F
Dog
Lupus familis
XP_531814
1283
145094
T527
K
G
N
L
S
T
E
T
K
M
I
L
K
G
S
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
T552
E
E
E
T
S
G
H
T
R
V
Y
G
V
C
F
Rat
Rattus norvegicus
XP_002726765
1361
151628
M555
E
E
D
S
S
G
H
M
R
A
Y
G
V
C
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
Q659
E
K
E
D
S
S
G
Q
R
V
Y
G
V
C
F
Frog
Xenopus laevis
NP_001089247
1340
149481
R532
M
D
D
S
S
G
Q
R
R
V
Y
G
V
S
F
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
H552
S
E
E
D
S
T
G
H
G
H
I
Y
G
V
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
E448
M
P
V
L
F
L
N
E
K
S
A
L
S
Q
R
Honey Bee
Apis mellifera
XP_392346
1120
127429
T378
G
V
C
F
L
D
T
T
I
G
D
F
Y
L
G
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
E444
I
V
V
Q
A
I
V
E
R
G
S
I
S
S
T
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
E525
I
A
R
V
E
Q
T
E
T
P
D
M
M
Q
E
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
E534
L
S
E
F
W
D
A
E
R
T
V
Q
E
V
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
F526
N
P
T
A
E
H
N
F
G
V
C
L
V
D
V
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
V500
L
D
T
L
M
S
Q
V
R
P
M
E
V
V
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
13.3
N.A.
80
93.3
N.A.
N.A.
53.3
60
13.3
N.A.
0
6.6
6.6
0
P-Site Similarity:
100
N.A.
100
33.3
N.A.
93.3
93.3
N.A.
N.A.
66.6
66.6
20
N.A.
20
6.6
13.3
6.6
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
7
0
7
0
0
20
7
0
0
0
0
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
7
0
0
34
7
% C
% Asp:
0
14
27
14
0
14
0
0
0
0
14
0
0
7
0
% D
% Glu:
34
34
27
0
14
0
7
27
0
0
0
7
7
0
7
% E
% Phe:
0
0
0
14
7
0
0
7
0
0
0
7
0
0
40
% F
% Gly:
7
7
0
0
0
34
14
0
14
14
0
40
7
7
7
% G
% His:
0
0
0
0
0
7
27
7
0
7
0
0
0
0
0
% H
% Ile:
14
0
0
0
0
7
0
0
7
0
14
7
0
0
0
% I
% Lys:
7
7
0
0
0
0
0
0
14
0
0
0
7
0
7
% K
% Leu:
14
0
0
20
7
7
0
0
0
0
0
20
0
7
0
% L
% Met:
14
0
0
0
7
0
0
7
0
7
7
7
7
0
7
% M
% Asn:
7
0
7
0
0
0
14
0
0
0
0
0
0
0
0
% N
% Pro:
0
14
0
0
0
0
0
0
0
14
0
0
0
0
0
% P
% Gln:
0
0
0
7
0
7
14
7
0
0
0
7
0
14
0
% Q
% Arg:
0
0
7
0
0
0
0
7
60
0
0
0
0
0
7
% R
% Ser:
7
7
0
27
54
14
0
0
0
7
7
0
14
14
7
% S
% Thr:
0
0
14
7
0
14
14
34
7
7
0
0
0
0
7
% T
% Val:
0
14
14
7
0
0
7
7
0
27
7
0
54
20
7
% V
% Trp:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
40
7
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _